LPS Poly I:C Overview
Cathelicidin iE-DAP MDP NO DNA DNA High extracellular Ca2+ K+ 2'-5'olig(A) Hcys dsDNA Defensins DNA ATP dsDNA CA2+ Ca2+ IP3 DNA DNA T3SS DNA ER ROS LPS DNA dsRNA Toxins Bacteria Pyroptosis T3SS rod DNA virus T3SS needle DNA virus RNA virus Cytosolic bacteria Phagocytosis Cytosolic LPS Yersinia bacteria Gram-negative bacteria NAIP ASC PLCB1 CARD8 ANTXR1 BIRC2 ERBB2IP MAPK13 ASC NLRP3 NLRP12 BCL2 NOD2 TRPV2 GBPs STAT1 GBPs IL1B CASP4 OAS MCU IL18 NFKB1 IRF7 MAPK8 NLRP1 LUBAC TXNIP CCL5 IL8 CASP1 MAVS ITPR2 IFI16 ERK TAB3 NOD2 GPRC6A PA TRAF6 IL1B NAMPT IL18 CASP1 RIPK1 CARD9 CASP1 TRPM7 IKBKB TAB2 LF ANTXR2 MAPK12 ITPR1 CHUK CARD6 IFNA CASP5 ASC PA MFN2 GABARAPL2 XIAP MAPK10 POP3 IRF7 RHOA PSTPIP1 IRAK4 IRF7 RIPK2 CASP11 AIM2 PLCB2 SUGT1 GP91 IFI16 BRCC3 XIAP MFN1 Pyrin IFNAR1 YopJ NFKBIA NEK7 ASC CASP1 TAK1 MAPK14 ITPR3 NFKB1 JAK1 VDAC3 NLRP7 TNFα NFKB1 RIPK2 NLRP6 MYD88 ASC TP53BP1 IKBKB DRP1 pro-IL-1β GSDMD IL18 CTSB RNASEL TLR4 IFI16 IL1B MAVS IFI16 pro-IL-1β NLRC4 IRF9 TRAF6 TBK1 BCL-XL MCP-1 Pyrin ASC MAPK9 CASP1 IFI16 PRKCD GABARAPL1 HSP90 POP2 p22phox IKBKE MAPK11 SUGT1 PANX1 Flagellin TMEM173 TICAM1 IFNA Nemo IL6 TRPM2 TXN TAB1 TRAF3 ASC NLRP12 IL18 VDAC2 DHX33 NOD1 ASC CASP1 TRIP6 CASP1 Nemo IFNA NLRP12 ASC CASP1 ANTXRL ATG16L1 P2RX7 TXN2 TNFAIP3 ATG5 TRAF2 CXCL NLRX1 CASP11 TANK TRAF5 NOD2 TYK2 PLCB4 IFNA JUN POP1 ASC TBK1 NFKBIA CASR IL18 CASP1 CASP1 VDAC1 IFNAR2 LF ATG12 CASP12 CARD CASP8 pro-CASP1 FADD Acylated lipopeptides Stress Epithelial cell damage IFN-stimulated genes Pathogenic bacteria Bacterial PGN Pro-inflammatory effects Gram-negative bacteria Gram-negative bacteria gene Chemokines Mitocondria disfunction Antimicrobial peptides K+ efflux Peptidoglycan biosynthesis bacterial toxin PAMPs DAMPs Inflammasomes ssRNA virus MAPK signaling pathway Bacterial secretion system Proteasome Damaged lysosome NF-kappa B signaling pathway Pro-inflammatory cytokines Toll-like receptor signaling pathway JNK p38 NOD-like receptor signaling pathway - Anas platyrhynchos (mallard) - S. aureus Endosome Mitochondria Endosome