S. aureus LPS Overview
Cathelicidin iE-DAP MDP NO DNA Hcys High extracellular Ca2+ DNA Defensins DNA dsDNA IP3 K+ DNA ATP CA2+ Ca2+ dsDNA 2'-5'olig(A) DNA DNA ROS LPS T3SS DNA ER dsRNA DNA virus Toxins Pyroptosis Bacteria T3SS rod T3SS needle DNA virus RNA virus Gram-negative bacteria Phagocytosis Yersinia bacteria Cytosolic bacteria Cytosolic LPS SUGT1 ASC CCL5 PLCB1 NLRP3 PRKCD ANTXR1 TXNIP ITPR2 NAIP NFKBIA IFNA IL1B MAPK10 MAPK9 ASC GABARAPL2 TAB3 RIPK2 MFN2 TRAF2 IL18 RHOA NFKB1 CASP1 MAPK11 XIAP POP1 p22phox CASP4 LF TRAF3 DRP1 IRAK4 IL18 CASP1 IKBKE CARD9 RIPK2 NLRP12 IL18 TNFα NLRP1 BRCC3 PSTPIP1 TBK1 IFI16 ASC NLRC4 IL18 POP3 IRF7 IKBKB JAK1 LUBAC IFI16 Pyrin ANTXRL PLCB4 GBPs HSP90 ASC TYK2 YopJ CASP1 ATG16L1 ASC TRAF5 MAVS ASC TRIP6 CASP1 JUN OAS Nemo NOD2 CASP11 PLCB2 BCL2 VDAC3 IFNAR1 GABARAPL1 PANX1 TLR4 pro-IL-1β ASC NOD2 IFI16 MFN1 NLRX1 DHX33 GPRC6A IFNA MAPK13 CTSB NFKBIA ERK TRAF6 IKBKB RIPK1 IL8 NEK7 CASP1 XIAP ANTXR2 TXN pro-IL-1β NLRP12 ERBB2IP STAT1 ITPR3 NLRP12 IRF7 GP91 IFNA GSDMD ASC CASP1 IL6 AIM2 BCL-XL CXCL NOD2 CASP11 VDAC1 CARD6 IFNA CASP1 BIRC2 IFNAR2 TRPM7 Nemo TNFAIP3 CASP1 PA TP53BP1 ASC TXN2 LF CHUK TBK1 IL1B MAPK14 MAVS P2RX7 TANK CASP1 NFKB1 POP2 TRAF6 IRF7 TRPV2 CASP1 MAPK12 IRF9 MCU ITPR1 NLRP6 TMEM173 Flagellin TAK1 RNASEL GBPs NLRP7 PA CARD8 NFKB1 NAMPT VDAC2 MAPK8 MYD88 IL1B ATG5 TICAM1 ASC IFI16 IL18 NOD1 TAB2 SUGT1 Pyrin MCP-1 CASR IFI16 TAB1 CASP5 TRPM2 ATG12 CASP12 CARD CASP8 FADD pro-CASP1 Acylated lipopeptides Stress Epithelial cell damage Pathogenic bacteria IFN-stimulated genes Bacterial PGN Pro-inflammatory effects Gram-negative bacteria Gram-negative bacteria gene Chemokines K+ efflux Antimicrobial peptides Mitocondria disfunction ssRNA virus PAMPs DAMPs Inflammasomes Peptidoglycan biosynthesis bacterial toxin MAPK signaling pathway Damaged lysosome Proteasome Bacterial secretion system NF-kappa B signaling pathway Pro-inflammatory cytokines Toll-like receptor signaling pathway JNK p38 NOD-like receptor signaling pathway - Anas platyrhynchos (mallard) - Poly I:C Mitochondria Endosome Endosome