LPS Poly I:C Overview
B-cell proliferation Class switch recombination Somatic hypermutation M cell Epithelial cell Intestinal immune network for IgA production - Anas platyrhynchos (mallard) - S. aureus RA Isolated lymphoid follicles MHC class II Peyer's patch Vascular system Inductive site Antigen DC B1 cell Homing Antigen DC Bacteria CD4+ T-cell Gut lumen IgA+plasmablast IgA+ plasmablasts SIgA IgA+ B-cell IgA+plasma cell IgA+ B-cell Recirculation Anpl-DRA MADCAM1 TCR ICOS ICOSLG IL4 Anpl-DRA TNFSF13B IGH CD28 CCR9 TNFRSF13B IL5 IL5 ITGA4 AICDA IL6 pIgR IL10 APRIL CD80 IL-2 TNFSF13B IL5 IL-2 TNFRSF13B TCR TGFB1 IL10 AICDA MAP3K14 IL15RA CD40 IL6 BAFFR CXCL12 CCL25 CD40LG ITGA4 IL4 CXCR4 TGFB1 TGFB1 TNFSF13 CCR9 IGH IGH IL6 IL15 CCL28 TNFRSF13B TNFRSF17 IL10 CD86 LTBR CCR10 Lamina propria gene Effector site Lamina propria Class switch recombination Somatic hypermutation Lamina propria stroma cell Lamina propria stroma cell Terminal B cell differentiation Leukocyte transendothelial migration B cell receptor signaling pathway Antigen processing and presentation T cell receptor signaling pathway B2 cell B1 cell High endothelial venules