LPS PIC Overview
dsRNA dsRNA       α2-3 SA (Avian influenza H5N1) ROS PIP3 HA1 OxPL ssRNA        α2-6 SA    SA 2'-5' oligo(A) H+ HA2 PB1-F2 Apoptosis KPNA1 KPNA2 RAF1 PABII MAPK11 TMPRSS4 FASLG PA Plasmin OAS PIK3CA CXCL10 PB1 HSPA2 MAP2K6 HAT AKT1 PKCB11 GSK3B NS2 NFKBIA NS1 TMPRSS13 PIK3CB MAP2K1 Anpl-DRA NLRP12 M1 TNFSF10 TLR7 CYC MAP2K7 TNFRSF1A FURIN TMPRSS2 TLR3 ATF2 HA1 Raf2p48 PIK3R2 MDA5 MAPK13 EIF2AK2 NS1 AKT3 MxA MAPK9 NFKB1 XPO1 IL6 EIF2S1 IRF7 TNFA STAT1 IRF3 NXF1 EIF2AK4 ASC CCL5 HA MAPK8 M1 MAPK12 M2 ACTB NP IL1B IRAK4 ICAM1 MAP2K4 ACTRT2 MAVS NXT2 DNAJC3 NUP98
NS1 IFNAR1 MCP1 ACTG1 HA NA CASP9 IFNB NA AGFG1 MAP2K3 IRF9 CIITA IL33 PML Clara AKT2 PB2 HSP40 EIF2AK1 IFNAR2 EP300 EIF2AK3 PIK3R1 JAK1 ANT3 TLR4 RSAD2 MYD88 PB2 MAP2K2
MAPK1 IFNGR1 SOCS3 IL12B trypsin-I JAK1 NP PRKCA TRIM25 RNASEL PIK3CD IL1B VDAC1 IKBKB CREBBP Rae1 PB1 IL8 IFNB RIG-I Tyk2 NLRX1 IFNG NS2 JAK2 E1B-AP5 HSPA8 PLG PA M2 PIK3R3 JUN STAT1 MAPK14 INFA CPSF4 TICAM1 MAPK10 IL12A CASP1 NS1 NS1 IL18 IVNS1ABP OAS IFNGR2 ADAR CPSF4L Endocytosis RNA transport Viral myocarditis Viral myocarditis gene NOD-like receptor 
signaling pathway MAPK signaling pathway Terpenoid backbone 
biosynthesis Cellular mRNA mRNA surveillance pathway RIG-I-like receptor 
signaling pathway T cell activation 
 Antibody response T cell activation 
 Antibody response Jak-STAT signaling 
pathway Viral RNP export 
 Viral protein expression Viral RNA synthesis Alveolar and bronchial epithelial cells 
 Alveolar macrophages 
 Type II pneumocytes 
 Plasmacytoid dentritic cells Virus-host cell fusion 
 Release of viral genetic material Viral RNP export 
 Viral protein expression Hsp70 AP1 Inhibited mRNA export Inhibited 3'-end processing 
 Inhibited host gene expression Alveolar epithelial cell death High fever 
 Acute respiratory distress syndrome Inhibited premature apoptosis Inflammasome Virus release Virus budding Avian influenza Influenza A virus Influenza A virus PKR p38 JNK Chemptraction of monocytes and macrophages Chemoattraction of monocytes and macrophages Influenza A - Anas platyrhynchos (mallard) - S. Aureus IKBKE TBK1